aimosti

Frequently asked.

Do you sequence my DNA?

No. Aimosti never takes a sample or sequences anything. You bring whole-genome data you already had produced (e.g. from Nebula, Dante, Sequencing.com); we re-analyse the variant file against current databases.

Is this a medical test or a diagnosis?

No. Every finding is a literature match against public databases: information to discuss with a clinician and confirm with a validated gene test. It is never a diagnosis or medical advice.

What files do you accept?

A whole-genome gVCF gives the most complete report: it records which regions your sequencing covered, so "not found" can mean "examined and clear", not just absent. A plain VCF also gives the full report, read as variant-only (an absence could be the reference allele or an uncovered position). If you've had whole-genome sequencing from a provider like Nebula Genomics, Dante Labs or Sequencing.com, you're good to go — upload the gVCF if your provider offers one (an aligned-reads file BAM/CRAM also unlocks the Deep Read add-on, which runs a 29-gene pharmacogenomic panel (CYP2D6 + more) and measures per-gene callability). You can also upload raw data from a genotyping chip (23andMe, AncestryDNA or MyHeritage), which drives traits, per-variant-transparent pharmacogenomics (each defining SNP shown as typed on your array or not) and ancestry. The full clinical-findings panel and carrier status need a sequenced genome (WGS); a chip only reads a fraction of those positions, though a chip can still surface a few specific single-variant findings (such as Factor V Leiden and Prothrombin G20210A), shown for that variant only.

Exactly which genes, conditions and traits do you analyse?

No buying blind. Here is every gene, condition and trait we examine, grouped by module with its count, generated live from the same registries your report uses, so it can't drift from what we actually ship. Everything below is in the full report, except the Deep Read panel (the aligned-reads add-on); a genotyping-chip file unlocks a lighter subset. Open the full coverage page →

Clinical findings

39 items examined

Restated from ClinVar · ACMG SF v3.3

Pathogenic / likely-pathogenic variants in these genes, framed as personal risk. Needs a sequenced genome (WGS); a chip reads only a couple of these.

  • X-linked adrenoleukodystrophy ABCD1
  • Arrhythmogenic right ventricular cardiomyopathy PKP2, DSP, DSC2, DSG2, TMEM43
  • Biotinidase deficiency BTD
  • Cerebrotendinous xanthomatosis (CTX) CYP27A1
  • Catecholaminergic polymorphic ventricular tachycardia (CPVT) RYR2, CASQ2, TRDN
  • Dilated cardiomyopathy (inherited) LMNA, FLNC, TTN, BAG3, DES, RBM20, PLN
  • Fabry disease GLA
  • Factor V Leiden thrombophilia F5
  • Familial hypercholesterolemia LDLR, APOB, PCSK9
  • Familial adenomatous polyposis APC
  • Hereditary Breast and Ovarian Cancer BRCA1, BRCA2
  • Hereditary paraganglioma-pheochromocytoma SDHB, SDHC, SDHD, SDHAF2, MAX, TMEM127
  • Heritable thoracic aortic disease TGFBR1, TGFBR2, SMAD3, ACTA2, MYH11
  • Hereditary haemorrhagic telangiectasia (HHT) ACVRL1, ENG
  • Hypertrophic cardiomyopathy MYH7, MYBPC3, TNNT2, TNNI3, TPM1, MYL3, MYL2, ACTC1, TNNC1, PRKAG2
  • Juvenile polyposis syndrome BMPR1A, SMAD4
  • Li-Fraumeni syndrome TP53
  • Long QT syndrome KCNQ1, KCNH2, SCN5A, CALM1, CALM2, CALM3
  • Lynch syndrome MLH1, MSH2, MSH6, PMS2, EPCAM
  • Malignant hyperthermia susceptibility RYR1, CACNA1S
  • MUTYH-associated polyposis MUTYH
  • Marfan syndrome FBN1
  • Multiple endocrine neoplasia type 1 MEN1
  • Multiple endocrine neoplasia type 2 RET
  • Maturity-onset diabetes of the young (HNF1A-MODY) HNF1A
  • NF2-related schwannomatosis (neurofibromatosis type 2) NF2
  • Ornithine transcarbamylase (OTC) deficiency OTC
  • Peutz-Jeghers syndrome STK11
  • Pompe disease GAA
  • Prothrombin G20210A thrombophilia F2
  • PTEN hamartoma tumour syndrome PTEN
  • Hereditary retinoblastoma RB1
  • RPE65-related retinal dystrophy RPE65
  • Hereditary transthyretin amyloidosis TTR
  • Tuberous sclerosis complex TSC1, TSC2
  • Vascular Ehlers-Danlos syndrome COL3A1
  • Von Hippel-Lindau syndrome VHL
  • Wilson disease ATP7B
  • WT1-related Wilms tumour predisposition WT1

Carrier status

55 items examined

Restated from ACMG Tier 3 · ACOG carrier panel

A recessive-lens read for family planning. Needs WGS.

  • MCAD deficiency carrier ACADM
  • Aspartylglucosaminuria (AGU) carrier AGA
  • APECED (autoimmune polyendocrinopathy) carrier AIRE
  • Canavan disease carrier ASPA
  • Citrullinemia type I carrier ASS1
  • Wilson disease carrier ATP7B
  • Maple syrup urine disease carrier BCKDHB
  • GRACILE syndrome carrier BCS1L
  • Bloom syndrome carrier BLM
  • Biotinidase deficiency carrier BTD
  • Cystic fibrosis carrier CFTR
  • CLN5 disease carrier CLN5
  • Northern epilepsy (CLN8) carrier CLN8
  • Usher syndrome type 3A carrier CLRN1
  • Cystinosis carrier CTNS
  • Imerslund-Gräsbeck syndrome (B12 malabsorption) carrier CUBN
  • Cerebrotendinous xanthomatosis (CTX) carrier CYP27A1
  • Smith-Lemli-Opitz syndrome carrier DHCR7
  • Familial dysautonomia carrier ELP1
  • Tyrosinemia type I carrier FAH
  • Fanconi anemia group C carrier FANCC
  • Glycogen storage disease type Ia carrier G6PC1
  • G6PD deficiency G6PD
  • Pompe disease carrier GAA
  • Krabbe disease carrier GALC
  • Galactosemia carrier GALT
  • Gaucher disease carrier GBA1
  • Non-syndromic hearing loss carrier (DFNB1) GJB2
  • Lethal congenital contracture syndrome 1 (LCCS1) carrier GLE1
  • Sickle cell & β-thalassemia carrier HBB
  • Tay-Sachs disease carrier HEXA
  • Hydrolethalus syndrome (HLS) carrier HYLS1
  • Mucopolysaccharidosis type I carrier IDUA
  • Cornea plana 2 (CNA2) carrier KERA
  • Congenital lactase deficiency carrier LCT
  • Mucolipidosis IV carrier MCOLN1
  • Meckel syndrome, Finnish type (MKS1) carrier MKS1
  • Congenital nephrosis, Finnish type (CNF) carrier NPHS1
  • Gyrate atrophy of the choroid and retina carrier OAT
  • Phenylketonuria (PKU) carrier PAH
  • Muscle-eye-brain disease (MEB) carrier POMGNT1
  • Infantile neuronal ceroid lipofuscinosis (CLN1) carrier PPT1
  • RAPADILINO syndrome carrier RECQL4
  • Cartilage-hair hypoplasia (CHH) carrier RMRP
  • Salla disease carrier SLC17A5
  • Diastrophic dysplasia (DTD) carrier SLC26A2
  • Congenital chloride diarrhea (CCD) carrier SLC26A3
  • Pendred syndrome / hearing-loss carrier SLC26A4
  • Lysinuric protein intolerance (LPI) carrier SLC7A7
  • Niemann-Pick disease type A/B carrier SMPD1
  • Mulibrey nanism carrier TRIM37
  • Infantile-onset spinocerebellar ataxia (IOSCA) carrier TWNK
  • Usher syndrome type 2A carrier USH2A
  • Cohen syndrome carrier VPS13B
  • PEHO syndrome carrier ZNHIT3

Pharmacogenomics

8 items examined

Restated from CPIC guidelines

How your genotype may affect specific medicines, restated from CPIC. On a chip, only the genes whose defining SNPs your array typed.

  • CYP2C19
  • CYP2C9
  • CYP4F2
  • DPYD
  • HLA-B
  • NUDT15
  • SLCO1B1
  • VKORC1

Single-gene reads

5 items examined

Restated from ClinVar · peer-reviewed literature

  • APOE Alzheimer's-risk ε-genotype (reveal-gated)
  • Lp(a) Lipoprotein(a) cardiovascular-risk level
  • HFE Hereditary haemochromatosis (iron overload)
  • ABO ABO blood group, not a blood test
  • APOL1 APOL1 kidney-risk variants

Traits

23 items examined

Restated from NHGRI-EBI GWAS Catalog

Benign, well-replicated traits that clear a strict evidence gate.

  • Alcohol flush response
  • Alcohol metabolism speed (ADH1B)
  • Asparagus urine smell detection
  • Bitter taste sensitivity (TAS2R38)
  • Caffeine metabolism
  • Chronotype (morning vs evening tendency)
  • Cilantro (coriander) soapy taste
  • Coffee consumption tendency (AHR)
  • Duffy blood-group antigen (malaria resistance & neutrophil baseline)
  • Earwax type & body odour
  • Eye colour (blue vs brown)
  • Freckling tendency (IRF4)
  • FUT2 secretor status (norovirus resistance, gut microbiome, B12)
  • Hair colour shade (KITLG)
  • Hair thickness & shape
  • Lactase persistence
  • Androgenetic hair thinning tendency (TWIST2)
  • Muscle fibre type (ACTN3)
  • Omega fatty acid desaturation (FADS1)
  • Photic sneeze reflex (ACHOO)
  • Red hair and fair skin tendency (MC1R)
  • Vitamin B12 tendency (FUT2)
  • Vitamin D tendency (GC / VDBP)

Polygenic risk scores

4 items examined

Restated from PGS Catalog

A tendency across many variants and a percentile against a reference group, never a personal probability of disease. Reveal-gated.

  • Atrial fibrillation
  • Breast cancer
  • Coronary artery disease
  • Type 2 diabetes

Deep ancestry

2 items examined

Restated from PhyloTree

One thread of your tree per line, as global haplogroups, never a “percent ancestry” pie.

  • Maternal line, mtDNA haplogroup 11 clade families
  • Paternal line, Y-DNA haplogroup 14 clade families

Frontier

38 items examined

Restated from GWAS Catalog · emerging research

Exploratory; each reading labelled by how much evidence really backs it. Walled off from the clinical report, for curiosity, never medical.

  • Endurance vs power: the ACE 'sport gene'
  • ACTN3: fast-twitch 'sports gene' (sprint/power vs endurance)
  • ADORA2A: caffeine sensitivity & sleep
  • Alcohol flush: acetaldehyde clearance (ALDH2)
  • Alcohol metabolism speed (ADH1B)
  • BDNF: Val66Met, learning & neuroplasticity
  • Beta-carotene converter status (BCO1)
  • Risk-taking & processing speed (CADM2)
  • Caffeine metabolism: fast or slow (CYP1A2)
  • CCR5Δ32: the HIV-resistance deletion (read via a proxy SNP)
  • CLOCK: chronotype (morningness / eveningness)
  • Tendon stiffness & flexibility (COL5A1)
  • COMT: dopamine clearance ('warrior / worrier')
  • DRD2 / ANKK1: Taq1A, dopamine reward signalling
  • Novelty-seeking, the contested version (DRD4)
  • Anandamide tone (FAAH)
  • Omega-3/6 conversion efficiency (FADS1)
  • Stress-axis regulation, contested (FKBP5)
  • FTO: appetite & body-weight set-point
  • IGF2BP2: a lead type 2 diabetes marker
  • HDL & longevity curio (CETP I405V)
  • Longevity-associated FOXO3 variant
  • Klotho KL-VS: heterozygote-advantage curio
  • The 'warrior gene' myth (MAOA)
  • KIBRA memory-performance variant (WWC1)
  • MTHFR: C677T, the most over-hyped variant in consumer genetics
  • Glucose & melatonin crossover (MTNR1B)
  • Nicotine dependence signal (CHRNA5)
  • Mu-opioid receptor variant (OPRM1 A118G)
  • OXTR: rs53576, the oxytocin receptor & social behaviour
  • PPARGC1A: Gly482Ser, endurance & mitochondria
  • Secretor status: norovirus and B12 (FUT2)
  • Natural short sleeper: ADRB1
  • Natural short sleeper: DEC2 (BHLHE41)
  • Serotonin transporter (5-HTTLPR): the famous null
  • Glucose handling: the strongest common T2D variant (TCF7L2)
  • Vitamin-D tendency: activation enzyme (CYP2R1)
  • Vitamin-D tendency: binding protein (GC)

The Fringe

22 items examined

Restated from GWAS · speculative

The popular, playful gene-quirks, the deepest end of the firewall. For fun only.

  • Asparagus pee: can you smell it? (OR2M7 cluster)
  • Bitter taste: PTC taster or not (TAS2R38)
  • Blond vs darker hair (KITLG)
  • Cilantro tastes like soap (OR6A2)
  • Straight vs curly hair (TCHH)
  • Wet or dry earwax (ABCC11)
  • Blue or brown eyes (HERC2)
  • Can you taste fat? (CD36)
  • Freckles & premature greying (IRF4)
  • Rage at chewing sounds: misophonia (TENM2)
  • Motion sickness (carsick / seasick tendency)
  • Sun sneeze: the ACHOO reflex (near ZEB2)
  • Red hair & freckling (MC1R R151C)
  • Chili-heat sensitivity (TRPV1)
  • How sweet is sweet? Sucrose sensitivity (TAS1R3)
  • Sweet tooth (FGF21 'sugar hormone')
  • Tan vs burn: skin pigment (SLC45A2)
  • Tongue taste-bud density: gustin (CA6)
  • Hair thickness and shovel-shaped teeth (EDAR)
  • Umami (savory) taste sensitivity (TAS1R1)
  • Eyebrow convergence: the 'unibrow' nudge (PAX3)
  • Can you smell violets? Beta-ionone (OR5A1)

Deep Read: 29-gene pharmacogenomic panel Deep Read add-on

29 items examined

Restated from CPIC · PyPGx (from your aligned reads)

Resolved from aligned reads (BAM/CRAM), including CYP2D6 star-alleles a variant file can't call, with a measured per-gene callability map.

  • ABCB1
  • ABCG2
  • ALDH2
  • BCHE
  • CACNA1S
  • CYP1A2
  • CYP2B6
  • CYP2C19
  • CYP2C8
  • CYP2C9
  • CYP2C_rs12777823
  • CYP2D6
  • CYP3A4
  • CYP3A5
  • CYP4F2
  • DPYD
  • F2
  • F5
  • G6PD
  • GRIK4
  • IFNL3
  • MTHFR
  • NAT2
  • NFIB
  • NUDT15
  • SLCO1B1
  • TPMT
  • UGT1A1
  • VKORC1
What are the Frontier & Fringe modules?

Two optional, clearly-firewalled sections for emerging and exploratory research: the variants biohackers actually ask about: from caffeine and alcohol-flush metabolism to the natural short-sleeper genes and longevity curios, with the famous over-hyped ones (the “warrior gene”, the serotonin-transporter “depression gene”) shown for exactly what they are. The lighter Fringe collects the fun gene-quirks (cilantro-soap, red hair, spicy-food tolerance, misophonia). Each entry is labelled by evidence strength, contested and over-hyped included. For curiosity, never medical. How it's gated →

Where does my data live?

Stored in Finland (Helsinki), never leaving the EU, never sold or mined, deleted on demand. Full security story →

What does it cost?

€119 once for the full report. An optional €149 Deep Read add-on if you have aligned reads (BAM/CRAM): a 29-gene pharmacogenomic panel (CYP2D6 + more) plus per-gene callability. And an optional ≈€29/year re-analysis subscription. See pricing →

What is the re-analysis subscription?

Databases improve constantly. If you opt in, we keep only your small normalised variant file and silently re-match it as the science moves, then tell you what changed. Cancel any time; your last report is always yours.

Is this a subscription trap?

No. You pay once for the report and own it forever. The €29/yr only keeps it updating as the science moves; cancel anytime and you keep your last report. We never hold your report hostage.

Can I delete everything?

Yes, at any time, with one request or by deleting your account.

Is my data used to train AI?

No. Your genome is never used to train any model. We don't sell, share, or mine your data. Our business is the report, not your DNA. More on how we handle data →

What happens to my data if Aimosti shuts down?

Your data is never an asset we would sell. That's the whole lesson of the 23andMe bankruptcy. If we ever wind the service down, the commitment is export-first, then deletion: you can export what's yours, and then it is permanently deleted, never transferred to a buyer. Why we're built this way →

Can my insurer or employer get this?

Not from us. We never sell or share your data, and your report lives behind your account, in the EU, deletable on demand. (Genetic-discrimination protections vary by country; the US has GINA, and the EU/Finland has its own safeguards, but the simplest protection is that your data never leaves your control to begin with.)

Do you offer CYP2D6, HLA or other specialised genes?

The Deep Read add-on (€149) covers a 29-gene pharmacogenomic panel via aligned reads (BAM/CRAM): including CYP2D6, CYP2C19, TPMT, DPYD, SLCO1B1, NUDT15 and more. CYP2D6 is the flagship example: its gene structure (duplications, deletions, pseudogene interference) can't be resolved from a standard variant file; the same reads drive the wider panel. HLA typing is on our roadmap. We'd rather say "not from this file" than imply a result we can't stand behind.

Still curious? Contact us