What files Aimosti accepts
If a sequencing company or a consumer DNA test gave you a file, we almost certainly read it. Aimosti accepts five formats on two reference builds. Upload the file as your provider sent it. Do not unpack, convert, or rename it first.
The five formats
- BESTgVCFA sequenced genome that also records what was covered. You get the full report, and a variant that does not appear is reported as examined and clear rather than simply absent.
- FULLVCFA sequenced genome, variants only. You get the full report, as long as the genome behind it was sequenced at standard depth. Because the file does not say what was covered, an absence can mean "not present" or "not looked at". Nebula, Dante and Gencove ship this one.
- LIGHTChip raw dataThe genotyping-array export from 23andMe, AncestryDNA, MyHeritage, FamilyTreeDNA or LivingDNA. You get traits, ancestry, pharmacogenomics and a few named findings. You do not get the full clinical-findings or carrier panels.
- DEEPBAMAligned reads. These give you the Deep Read add-on: CYP2D6 copy number, per-gene callability, two deletions called from depth and typed HLA-DQ, alongside the full pharmacogene panel.
- DEEPCRAMAligned reads, compressed against a reference. Same result as a BAM. Bring the build it was written against.
Find your provider
- WGSNebula, Dante, Sequencing.com, GencoveYou have a sequenced genome. Upload the gVCF if they made you one. Otherwise upload the VCF; it gives the full report. Check which depth you bought, because these providers sell more than one: Nebula's DNA Complete comes in 1x, 30x and 100x versions, so the provider name on its own no longer tells us what your file can support. A 30x or 100x genome is the full report as described above. A 1x or 2x genome is a different product, not a broken one: at that depth the genotypes are worked out statistically against a reference panel rather than read directly, which is precisely how it is meant to work and is what makes it good for ancestry, traits and pharmacogenomics. What it cannot carry is the clinical-findings and carrier panels, because those turn on rare variants and a reference panel is weakest exactly there. So a low-pass genome is the €19 report rather than the €2 one. We would rather read your file at the right price than turn you away: tell us what you have and we will set it up.
- CHIP23andMe, AncestryDNA, MyHeritage, FamilyTreeDNA,
LivingDNADownload your genotyping-array raw data and upload the
.zipunchanged. One vendor note: MyHeritage kits sold since October 2025 are sequenced rather than typed on a chip. They still hand you a raw-data export in the same format, and it works here. Its genotypes are worked out from the sequencing rather than read straight off an array, and the file carries no Y chromosome, so there is no paternal line in it. - READSAny provider that gave you a BAM or CRAMUpload it for the €2 Deep Read. Pair it with a variant file for the full report, which is the combination worth having: your reads measure what was covered, so a finding missing from the variant file reads as examined rather than merely absent. If you already sequenced, what your reads add sets it out. Deep Read needs standard-depth reads. A low-pass file, MyHeritage's own sequencing download among them, is read about twice over rather than thirty times, which is too thin to call these genes from, so we measure the depth and stop rather than guess. Their raw-data export is the file to send us.
The detail, if you want it
Why is a gVCF better than a VCF?
A VCF lists only where you differ from the reference. It does not say which positions were read. So when a disease variant is not in the file, two explanations fit: you do not carry it, or the sequencer never covered that spot. A gVCF records the covered regions, which separates those two cases. Both files give the full report. The gVCF lets us say "examined and clear" instead of "not found".
What exactly does a chip file give me?
A genotyping chip reads a few hundred thousand chosen positions. A sequenced genome reads billions. From a chip you get traits, ancestry, and pharmacogenomics with every defining position shown as read, present but unresolvable, or absent from your chip. You also get a few specific findings that sit on standard chips, such as Factor V Leiden and Prothrombin G20210A, reported for that variant alone. You do not get the full clinical-findings panel or carrier status. Those need a sequenced genome, because a chip never reads most of those positions. We say so here rather than after you pay.
Which reference build do you support?
GRCh38 and GRCh37. Some providers, Dante among them, still deliver GRCh37. On GRCh37 the 29-target pharmacogenomic panel runs in full. The wider clinical coverage map and the recurrent-deletion screen are GRCh38-only; on a GRCh37 file we report them as not measured. We do not estimate them. Contig names match across builds, so a file read against the wrong build would produce numbers at the wrong coordinates instead of an error. That is why we detect the build from your file and act on what we find.
What do aligned reads add?
Reads are the evidence a variant file was summarised from. Some genes cannot be called from a summary at all. CYP2D6 is the standard example: duplications, deletions and a near-identical pseudogene defeat a variant file, and CYP2D6 drives the dosing of common antidepressants, painkillers and tamoxifen. The €2 Deep Read reads CYP2D6 copy number, measures how well each gene was covered, calls two recurrent deletions from depth and types HLA-DQ, and runs the 29-target panel on the way.
Do I need to unzip or convert anything?
No. Gzipped, bgzipped and zipped files all work. Send the file the way your provider sent it. Converting it yourself is the most common way to break it.
What can you not use?
Three things. Unaligned reads (FASTQ): align them first, or ask your provider for the variant file. Multi-sample and trio VCFs: upload one person per file. Sites-only VCFs that carry no genotypes: the file lists positions but not what you carry. We reject these at upload and tell you which one it was, rather than analysing a file we cannot read correctly.
How long does a report take?
Most whole-genome reports on GRCh38 are ready 5–15 minutes after the upload finishes. A GRCh37 file is lifted to GRCh38 first, and a large gVCF on that build can take a couple of hours. Deep Read takes about half an hour once the reads are in. We email you when it is done, so there is no need to keep the tab open.
Check your file before you pay
Open it on the file check page. We read the header in your browser and tell you the format, the reference build, and what report it supports. Nothing uploads.
€2 for the full report · See pricing · See exactly what we examine