Compared · Promethease
Promethease costs $25 and takes ten minutes. Here is what that buys, and what it does not.
Promethease matches a DNA file to SNPedia for $25 a report. If all you want is every SNPedia entry your genotypes touch, it is the right purchase and this page will not talk you out of it. The differences start after the report arrives.
Where Promethease wins
Speed, and the price of a genome. Its homepage says "Most reports cost $25 and are produced in under 10 minutes", with additional files at $4 each. Each report is a one-time purchase with no subscription. Here a chip report is $19 and a whole-genome report $39, so for a whole-genome file Promethease costs less.
The size of SNPedia. Promethease "builds a personal DNA report based on connecting a file of DNA genotypes to the scientific findings cited in SNPedia", a wiki that MyHeritage's own acquisition announcement described as citing over 30,000 peer-reviewed publications. Our panel is a few hundred curated items, plus ClinVar's listed variants in 1,415 more genes on a sequenced file. If you want the long tail, the wiki has it.
Deletion. Its privacy page says the uploaded file and the report "are deleted immediately from Promethease after the Report is sent", and an unused upload after 24 hours. That is a clean custody story and we credit it.
Where the two differ
| Promethease | Aimosti | |
|---|---|---|
| Price for a file you own | $25 per report, $4 per extra file (its homepage) | $19 chip · $39 whole genome · $49 reads panel |
| What it reads | Genotype files; "imputed full genomes" run slower (its homepage) | Chip exports, VCF, gVCF, and BAM or CRAM for the reads panel |
| What the report is | Your genotypes matched to SNPedia entries, one list | Fixed, named panels graded into three evidence tiers, each finding attributed to a pinned source version |
| Pharmacogenomics | SNPedia entries where they exist | CPIC star alleles from a VCF (up to 25 genes from a gVCF, each stating how many defining positions the file examined); from reads, CYP2D6 copy number, per-gene callability, two deletions called from depth and typed HLA-DQ |
| What it says when the file cannot answer | Nothing; a missing position is simply not in the list | Reported as absent, not examined and clear; a gene the reads cannot cover is declined |
| Where the file goes | Processed in the United States (its privacy page); deleted after the report is sent | Processed and stored in Finland; deleted after analysis by default |
| Owner | MyHeritage, since its September 2019 acquisition of SNPedia and Promethease (MyHeritage's own announcement) | Aimosti Oy, Finland |
What this changes for a whole-genome file
A Promethease report on a 30x genome is a much longer list, not a different kind of report. Its entries are sorted by SNPedia's magnitude, which SNPedia defines as "a subjective measure of interest", not by a grade of the evidence behind them, and the report cannot tell you whether an absence means clear or unread. Here the panel is graded, the source is pinned, and a variant-only VCF's silence is reported as silence. With the aligned reads, the pharmacogenomic panel is called from the reads themselves, which is the only way to see CYP2D6 duplications and deletions, and the report records how much of each gene was actually covered. A one-page hand-off for a prescriber comes with every analysed report.
If you run both, that is a reasonable thing to do. The $25 list and the graded read answer different questions.
Promethease is described from its own public pages as read on 15 October 2026. Prices are quoted as displayed that day, in the currency shown there, and features change. We do not speak for Promethease. If something here is out of date, tell us and we will correct it.
See what a graded read of your file looks like before you decide.
Other comparisons: Genetic Lifehacks · SelfDecode · Gene2Rx · Sequencing.com · all five