Compared · SelfDecode
SelfDecode covers more ground than any consumer service. This one covers less, and says which ground.
SelfDecode's homepage counts "1500+ Comprehensive DNA Health Reports", adds your lab results, and puts an AI coach on top. It is the broad, polished option and it is honest about how it gets there. The difference is what each service does with a position it did not read.
Where SelfDecode wins
Breadth. "1500+ Comprehensive DNA Health Reports", "35+ health topics", "130+ condition reports" and "25+ longevity risk assessments", in its own homepage figures. Our whole-genome report examines a panel in the low hundreds of items, listed by name. On count, there is no contest and we do not pretend otherwise.
Everything around the genome. Lab-result analysis, lifestyle inputs, a "24/7 AI Health Coach" and DecodyGPT, and a plan that updates as you add data. We read a genetic file and stop. That is a narrower product by design, and for some readers the wrong one.
Candour about imputation. Its help centre explains that it takes roughly 650,000 tested variants and imputes "up to 200 million", states an average accuracy around 99.7%, says imputation "is much less accurate for rare SNPs of less than 1% minor allele frequency", and says it does not rely on imputed calls for genes such as APOE or BRCA1 and BRCA2. That is the clearest limitations page in this segment, and we credit it.
Where the two differ
| SelfDecode | Aimosti | |
|---|---|---|
| Price for a file you own | $319 for "Upload Your DNA" (its upload page); kit bundles from $499; renewals listed at $300 a year on its family-plan page | €49 chip · €89 whole genome · €109 reads panel, one-time; optional €29/year re-analysis |
| What it reads | Array exports from a long provider list; WGS VCF as .vcf.gz, "10x coverage or higher", named providers Dante Labs and Nebula; "we do not accept Whole Exome Sequencing (WES) files"; no BAM or CRAM mentioned (its help centre) | Chip exports, VCF, gVCF, exome VCF, and BAM or CRAM for the reads panel; a low-pass genome served at the chip tier rather than refused |
| Positions it did not read | Imputed, with the stated safeguards | Never imputed; reported as not read |
| Pharmacogenomics | Guidelines "based on evidence from CPIC, FDA, DPWG, and PharmGKB"; "does not detect all variants, or gene deletions and duplications outside the listed alleles" (its PGx report page) | CPIC star alleles from a VCF; a 29-gene panel called from reads, CYP2D6 duplications and deletions included; a gene the reads cannot cover is declined |
| Uploaded files | "Uploaded DNA files do not include all SelfDecode features and reports due to third-party DNA analysis being incomplete, less accurate, not validated" (its upload page) | The uploaded file is the product; the panel is the same whoever sequenced you, and the report says what the file could and could not support |
| Where the file goes | Third-party cloud storage; for EEA and UK users "data centers located within the European Union" (its privacy policy) | Processed and stored in Finland; deleted after analysis by default |
| AI | DecodyGPT and an AI health coach | None, by design |
What "not imputed" means for a genome
Imputation is a sound way to make a chip file say more, and SelfDecode uses it well. A 30x genome does not need it; every position was read, and the useful question becomes whether a given position was read in your file. A variant-only VCF cannot answer that, so here its silence is reported as absent rather than as clear. A gVCF can answer it, and is read as examined and clear where it earns that. The aligned reads answer it for the whole panel, gene by gene, and they are the only way to see what CYP2D6 is structurally doing, which SelfDecode's own PGx page says it does not detect. Every analysed report here ends in a one-page hand-off for a prescriber.
If breadth and coaching are what you want, SelfDecode is the better buy and this page will not argue. If you want to know exactly what was examined in your file, and what was not, that is the whole of this product.
SelfDecode is described from its own public pages as read on 3 September 2026. Prices are quoted as displayed that day, in the currency shown there, and features change. We do not speak for SelfDecode. If something here is out of date, tell us and we will correct it.
See what a panel that says where it looked reads like.
Other comparisons: Promethease · Genetic Lifehacks · Gene2Rx · Sequencing.com · all five