Dante Labs whole-genome data
What to do with your Dante Labs files
Dante sequenced you at 30x and handed over a FASTQ, a BAM and a VCF. The reports came from one reading of one file. The files themselves have not aged, and two of them still hold answers nobody has read out. Aimosti reads them in Finland and attributes every finding to its source.
Get both · €169 See a sample report first
€89 for the full report from your VCF · €109 for the Deep Read panel from your BAM · €169 prepaid together.
The three files in your Genome Manager
Dante's product pages promise "unrestricted access to your BAM, VCF, and FASTQ files", downloadable from the portal it calls Genome Manager. Each is the same genome at a different stage of processing, and each is a different size.
- The VCF is the list of positions where you differ from the reference genome, usually well under a gigabyte. It is what Dante's own reports were generated from, and it is the file for the €89 full report here: clinical findings, carrier status, pharmacogenomics from the variants a VCF can carry, traits, ancestry and the polygenic scores.
- The BAM is the aligned reads, tens of gigabytes. It records what the sequencer saw at every position, which is why it can answer two things a VCF cannot: whether a gene was actually covered, and what the structurally awkward pharmacogenes such as CYP2D6 look like. That is the €109 Deep Read panel. You do not upload the whole BAM; the browser sends only the slices the panel reads.
- The FASTQ is the unaligned reads. We do not use it. Keep it anyway; it is the only file from which everything else can be rebuilt.
Dante does not state on its pages which reference build its files are on, and Dante files have arrived here on both GRCh37 and GRCh38, depending on when the genome was sequenced. Nothing is asked of you: the file check reads the build from the header and a GRCh37 file is lifted before analysis. The lift is the slow part. A GRCh38 VCF is usually ready in about a quarter of an hour; a large GRCh37 file can take a couple of hours.
What a second reading adds
Dante's reports are one interpretation, made once, on the day they were generated. ClinVar and the CPIC guidelines have moved since then, and they keep moving. A re-analysis here reads the same VCF against the current pinned versions of those sources, prints the version of each one on your report, and lists every gene, condition and trait examined by name before you pay. Where the file cannot answer, the report says so instead of guessing: a variant-only VCF cannot tell "you are clear" from "nobody looked", so a clean result from it is reported as absent, never as examined and clear.
The BAM changes that. Deep Read measures depth across the whole report panel and counts the bases covered at 10x or better, so each gene comes back examined, partly examined, or not measured. The same reads drive the 29-gene pharmacogenomic panel to CPIC star-allele resolution, CYP2D6 included, and a one-page hand-off you can take to a prescriber. If the reads are too thin for a gene, the panel declines that gene rather than calling it.
Where Dante Labs stands today
This is history, not a warning, and every line of it is checkable. Dante Labs sold consumer whole-genome sequencing from Italy for years and was, for many people in Europe, the default way to get a 30x genome. On 23 December 2024 the law firm Clyde & Co announced that it had advised Bio Cell Tech FZCO, a company registered in the United Arab Emirates, on its acquisition of Dante Labs Genomics FZE, and that the acquired company had been renamed Lifespan Genomics Labs FZCO. The consumer site at dantelabs.com carries no notice of the change and still sells the 30x test.
Dante's own privacy policy says genetic information is kept for the life of the account plus up to three years after deletion, and that the biological sample is destroyed after sequencing unless you opt into storage. Its FAQ gives a different figure, ten years after deactivation, for personal data. We are not in a position to reconcile the two. The practical point is simpler: the copies of your files that you hold are the ones you control, so download them while the portal serves them, and keep them somewhere you own.
How to get your files out of Dante
- Sign in to your Dante Labs account and open the Genome Manager.
- Download the VCF first. It is the small file and the one the full report needs.
- Download the BAM and its index if you want the Deep Read panel. It is large, so give it a wired connection and time. Dante's FAQ says raw files can be "requested or downloaded where available", so if a download is not offered, ask their support for it.
- Store both somewhere private that you control. Do not rename, unpack or convert them; upload them as Dante delivered them.
Dante's download process is described from its public pages on 3 September 2026 and may change. We do not speak for Dante.
Your files do not leave the EU
Processing and storage are in Finland, under GDPR Article 9 special-category protection, and nothing crosses an EU border. The VCF you upload is deleted after analysis by default; the BAM slices are deleted the moment the Deep Read run finishes, whether it succeeded or failed. What we keep, with your consent and only if you want re-analysis later, is a small normalised variant file that you can delete from your dashboard at any time. Security & your data.
Check a Dante file before you pay
Drop the VCF or the BAM below. It is read inside this page, on your own device: nothing is uploaded, no account is needed, and you get back the format, the reference build and what report it supports.
Read on your device, not ours. Your file is never uploaded and no account is needed. We are a genomics company telling you not to send us your genome yet, and that is deliberate. Security & your data →
Reading on your device…
That's . We can build your report from it.
What it can tell you
What it can't
A chip reads a fixed set of common spots, so the rare-variant panels need a sequenced genome. We tell you this now rather than after you have paid.
One-time, yours to keep. Your file is still on your device: you upload it after checkout, over an encrypted connection, to storage in Finland.
That's : aligned reads.
This is exactly what the Deep Read pharmacogenomic panel needs: 29 targets read at base level, including the CYP2D6 star-alleles a normal VCF cannot reliably call. The standard report is built from a VCF/gVCF, so aligned reads sit alongside one rather than replacing it.
Deep Read needs standard-depth reads. A low-pass file, MyHeritage's own sequencing download among them, is read about twice over rather than thirty times, which is too thin to call these genes from. We measure the depth and stop rather than guess.
A CRAM also needs the exact reference assembly it was compressed against, not merely the same genome build. We hold the common ones and check yours before taking any money, so an assembly we cannot read is refused rather than charged for.
What the pair covers
The bundle is the whole-genome report plus the Deep Read panel. The report is built from a variant file and the panel from your reads, so it takes both. Most sequencing providers hand you both in the same download.
Nothing was uploaded, and you have not paid anything. We would rather turn a file away here than sell you a report it cannot support.
This check ran on your device from your file's header. We confirm the full file after upload, and never charge for a report we cannot build.
Common questions
The full report from your VCF plus the Deep Read panel from your BAM is €169, prepaid together. Both reports are yours to keep.
Sequenced elsewhere? Nebula and DNA Complete files · Sequencing.com files · Nucleus files · What your reads add, whoever sequenced you