traits

Lactose intolerance: the one variant most people actually have

Most adults worldwide stop making lactase after childhood. A single regulatory variant near LCT is why a minority keeps making it for life.

What the science says

A regulatory variant upstream of the LCT gene (in MCM6) keeps the lactase enzyme switched on into adulthood: "lactase persistence". It is the best-studied genetic input to lactose tolerance, but the gut you have on a given day also depends on dose, gut flora and adaptation.

What Aimosti would show you

Aimosti reads the common MCM6/LCT persistence variant from the DNA file you already own, a 23andMe or Ancestry export included, and restates the GWAS Catalog association, whether you carry the persistence allele, with evidence and effect kept separate, never as dietary instructions.

What we won't claim

We report the common genetic persistence variant, not your gut on a given day. We won't diagnose lactose intolerance, rule it out, or tell you what to eat: symptoms can have many causes this variant doesn't capture.

Covered in: Traits. Restated from: GWAS Catalog.