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Factor V Leiden: a common clotting risk factor, kept in proportion

Factor V Leiden sounds alarming, but how much does carrying it actually change your risk?

What the science says

Factor V Leiden (the F5 rs6025 variant) is the most common inherited clotting tendency, especially in people of European ancestry. One copy modestly raises the risk of venous clots (such as deep-vein thrombosis); two copies raise it more. Crucially, the absolute risk for most carriers stays low: the variant interacts with other factors like surgery, immobility, pregnancy and oestrogen-based contraception, which is exactly why it's useful to know in context rather than in isolation.

What Aimosti would show you

We restate the ClinVar classification for the F5 Leiden variant in your file, pinned to the record, framed as a common, well-established risk factor, not a disease. It ships with the modest-effect context above so it's read in proportion: a thing to mention to a clinician before situations that themselves raise clot risk.

What we won't claim

We won't call Factor V Leiden a clotting disorder or a diagnosis, and we won't estimate your personal odds of a clot: it's a common risk factor whose meaning depends on the rest of your situation, best weighed with a clinician.

Covered in: Clinical findings (ClinVar / ACMG SF). Restated from: MedlinePlus Genetics: F5 gene · MedlinePlus: Factor V Leiden thrombophilia.